DBCO-NH-C4-acid CAS:2375193-74-9 is a kind of DBCO acid contains an carboxylic acid group and a DBCO group. The carboxylic acid with an C4 spacer can conjugate with amine containing biomolecules. The resulting DBCO containing biomolecule readily reacts with azide bearing biomolecule through a copper-free click reaction instantly and in high yield.
DBCO-NH-C4-acid has been widely used in the development of novel drug conjugates and imaging agents. Its unique chemical properties enable the conjugation of therapeutic agents, such as antibodies or peptides, to the carboxylic acid group via amide bond formation. The resulting conjugates exhibit improved selectivity and efficacy, as well as reduced toxicity and immunogenicity.
In addition to its use in drug conjugation, DBCO-NH-C4-acid has also been employed as a tool for molecular imaging. For example, it can be conjugated with fluorophores or radioactive isotopes for in vivo imaging of specific biomolecules or biological processes.
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