DBCO-NH-C4-acid
This product is a heterobifunctional linker featuring a dibenzocyclooctyne (DBCO) group for copper-free click chemistry and a terminal carboxylic acid connected via a four-carbon (C4) spacer. This compact yet flexible design provides hydrophobic-to-hydrophilic balance, specifically enabling efficient bioorthogonal conjugation and biocompatible labeling.
Key Features and Benefits:
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DBCO Group: Supports strain-promoted azide–alkyne cycloaddition (SPAAC) without copper.
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Carboxylic Acid Group: Couples efficiently with primary amines to form amide bonds.
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C4 Spacer: Provides short, flexible separation for reduced steric hindrance.
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High Purity: Ensures reproducibility in sensitive bioconjugation workflows.
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Bioorthogonal Reactivity: Enables selective labeling in living systems without metal catalysts.
Applications:
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Click Chemistry: Copper-free SPAAC ligation with azides for in vitro and in vivo labeling.
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Bioconjugation: Facilitates dual-functional modification of proteins, peptides, and biomolecules.
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Drug Delivery: Supports PEGylated or compact linker–payload systems for targeted delivery.
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Surface Functionalization: Functionalizes nanoparticles, hydrogels, and biosensors.
Storage and Handling:
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Storage: Store at –20 °C in a sealed, light-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO) to maintain DBCO and acid stability.
This product combines copper-free click reactivity with carboxyl conjugation in a compact linker, making it an especially excellent choice for bioorthogonal labeling and dual-functional bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
