BCN-OH
This product is a high-purity strained cycloalkyne features a bicyclo[6.1.0]nonyne (BCN) for rapid, copper-free SPAAC with azides and a terminal hydroxyl for versatile derivatization. Ideal for live-cell labeling, surface functionalization, and drug delivery, the hydroxyl enables further modification via esterification, ether formation, or activation.
Key Features and Benefits
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BCN Group: Supports fast, copper-free click chemistry with azides for bioorthogonal labeling.
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Hydroxyl Group: Serves as a versatile site for further functionalization or linker attachment.
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Bioorthogonal Reactivity: Allows selective labeling in complex biological environments without toxic catalysts.
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Compact Design: Low steric hindrance ensures high reactivity and efficient conjugation.
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High Purity: Supplied at >95% purity for reproducible and consistent results.
Applications
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Bioorthogonal Labeling: Conjugate azide-containing biomolecules under physiological conditions.
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Protein and Peptide Modification: Introduce BCN groups to biomolecules for SPAAC reactions.
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Nanoparticle and Surface Functionalization: Attach BCN moieties to enable click chemistry-based surface engineering.
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Drug Delivery Systems: Create targeted delivery vehicles with clickable BCN handles.
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Chemical Biology Tools: Develop probes and sensors for live-cell imaging and diagnostics.
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Handling: Use anhydrous solvents such as DMF, DMSO, or dichloromethane; avoid prolonged exposure to moisture.
This high-purity strained cycloalkyne features a hydroxyl group, provides copper-free click reactivity with azides, and offers an especially versatile handle for chemical modification in bioorthogonal and materials science applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
