Auristatin E (CAS 160800-57-7) is a potent cytotoxic agent derived from Dolastatin 10. It inhibits tubulin polymerization, disrupting microtubule formation and inducing cell cycle arrest and apoptosis. It plays a key role as the payload in antibody-drug conjugates (ADCs) for targeted cancer therapy.
Key Features:
- CAS Number: 160800-57-7
- Mechanism: Blocks tubulin polymerization, leading to cell death
- Function: Cytotoxic agent in cancer treatment and research
- Applications:
- Integral to ADCs for precise cancer targeting
- Useful in studying microtubule dynamics and cancer cell apoptosis
Auristatin E provides high potency in ADCs, making it a powerful tool in targeted cancer therapies.
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