4-mercapto-4-methylpentanoic acid

4-mercapto-4-methylpentanoic acid

This product is a sulfur-containing carboxylic acid with a free thiol group and a branched alkyl backbone. The thiol enables selective conjugation through disulfide or maleimide chemistry, while the carboxylic acid provides coupling versatility, making it especially useful in bioconjugation, drug design, and material modification.

Key Features and Benefits:

• Thiol Group: Reacts selectively with maleimides, haloacetyls, and disulfides.

• Carboxylic Acid Group: Couples with amines to form stable amide linkages.

• Branched Structure: Offers steric bulk for specialized applications.

• High Purity: Ensures reproducibility in biochemical and synthetic workflows.

• Versatile Reactivity: Supports multifunctional conjugation strategies.

Applications:

• Bioconjugation: Useful for thiol–amine dual-reactive linker designs.

• Drug Discovery: Sulfur-functionalized intermediate for therapeutic payloads.

• Surface Modification: Functionalize polymers, nanoparticles, or hydrogels.

• Synthetic Chemistry: Precursor for thioester or disulfide-containing scaffolds.

Storage and Handling:

• Storage: Store at –20 °C in a dry, light-protected container.

• Handling: Work under inert atmosphere to prevent thiol oxidation.

This product combines thiol and acid functionality in a compact, branched structure, making it an especially versatile building block for advanced conjugation and synthetic chemistry.

AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.