M-PEG-Alcohol, also known as monomethoxy polyethylene glycol alcohol, is a polyethylene glycol derivative that contains a single methoxy group at one end and a hydroxyl group at the other end. This functional group arrangement gives M-PEG-Alcohol unique physicochemical properties that make it a versatile building block in pharmaceutical research and development.
The methoxy group, which is an ether functional group (-O-), enhances the water solubility of M-PEG-Alcohol and provides steric hindrance to prevent aggregation. The hydroxyl group (-OH) on the other end of the molecule allows for further modification, such as the addition of other functional groups or attachment to a drug molecule. These properties make M-PEG-Alcohol an ideal choice for drug delivery systems, as it can improve the solubility, stability, and pharmacokinetic properties of the drug.
M-PEG-Alcohol is commonly used in the development of liposomes, micelles, and nanoparticles for drug delivery applications. It can also be used as a surface modifier for medical devices and in tissue engineering. In addition, M-PEG-Alcohol can act as a stabilizer for proteins, peptides, and other biological molecules, preventing aggregation and denaturation.