endo-BCN-PEG2-acid

endo-BCN-PEG2-acid linker contains a BCN group and a terminal carboxylic acid. While the BCN group readily react with azide-functionalized biomolecules, the terminal carboxylic acid reacts with amine groups in the presence of coupling reagents such as EDC, DCC, HATU etc, to form a stable amide bond. The PEG spacer increases aqueous solubility of the resulting bioconjugates.

Ref:

1. Singh, S.S., Calvo, R., Kumari, A., Sable, R.V., Fang, Y., Tao, D., Hu, X., Castle, S.G., Nahar, S., Li, D. and Major, E., 2024. Fatty acid derivatization and cyclization of the immunomodulatory peptide RP-182 targeting CD206high macrophages improves anti-tumor activity. Molecular Cancer Therapeutics.

AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.