Thiol-PEG7-Azide (also known as Azide-PEG7-Thiol) is a heterobifunctional polyethylene glycol (PEG) linker with a seven-unit PEG spacer connecting terminal thiol (-SH) and azide (-N₃) groups. This structure enhances solubility and flexibility, making it ideal for various conjugation applications.
Key Features:
- Molecular Formula: C₁₆H₃₃N₃O₇S
- Molecular Weight: 411.51 g/mol
- Functional Groups: Thiol (-SH) and azide (-N₃)
- Solubility: Highly soluble in water and common organic solvents
Applications:
- Click Chemistry:
- The azide group efficiently reacts with alkynes or cyclooctynes via azide-alkyne cycloaddition, forming stable triazole linkages.
- Bioconjugation:
- The thiol group forms covalent bonds with maleimide-containing molecules or metal surfaces, enabling the attachment of biomolecules.
- Surface Modification:
- The thiol group binds to metal surfaces, such as gold, facilitating the functionalization of nanoparticles and biosensors.
Azide-PEG7-SH is a versatile reagent in chemical biology and materials science, enabling the development of complex molecular assemblies and advanced materials.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
