Tetrazine-PEG4-amine is a powerful reagent for bioconjugation and click chemistry. It features a tetrazine group that reacts rapidly with trans-cyclooctene (TCO) derivatives, enabling fast and catalyst-free labeling. This makes it perfect for live-cell imaging and in vivo applications.
Key Features:
- Tetrazine Group: Reacts quickly and specifically with TCO, ideal for precise bioconjugation.
- PEG4 Spacer: Improves solubility, reduces steric hindrance, and enhances biocompatibility.
- Amine Functional Group: Allows easy attachment to carboxyl groups or other reactive sites, expanding its use in functionalization and surface modification.
Applications:
- Bioconjugation: Easily label proteins, peptides, and other biomolecules, perfect for live-cell and targeted studies.
- Bio-orthogonal Chemistry: Perform selective, non-disruptive reactions in complex biological systems.
- Surface Modification: Attach biomolecules to surfaces and nanoparticles for research and industrial use.
Benefits:
- Rapid and Specific: Tetrazine’s fast reaction with TCO ensures efficient labeling.
- Copper-Free: Safe for sensitive biological systems without the need for toxic catalysts.
- Enhanced Solubility: The PEG4 spacer keeps conjugates soluble and reduces immune response.
Storage and Handling:
- Store at -20°C in a dry environment.
- Handle with standard safety measures for reactive reagents.
Tetrazine-PEG4-amine is a go-to choice in molecular biology and pharmaceutical research, offering unmatched speed and biocompatibility in bio-orthogonal chemistry.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
