Tetrazine-PEG4-Aldehyde is a bifunctional reagent featuring a tetrazine group for rapid, bioorthogonal IEDDA reactions with strained alkenes (e.g., TCO) and an aldehyde group for conjugation via oxime or hydrazone ligation. The PEG4 spacer enhances solubility, reduces steric hindrance, and ensures biocompatibility, making it a powerful tool for bioconjugation, imaging, and chemical biology applications.
Features
- Tetrazine Group: Enables fast and selective IEDDA bioorthogonal conjugation.
- Aldehyde Group: Reacts with amines, hydrazides, or oxyamines for stable linkage.
- PEG4 Spacer: Enhances solubility and minimizes steric interference.
- High Purity: ≥95% for reliable experimental results.
- Biocompatibility: Suitable for complex biological systems.
Applications
- Bioconjugation: Site-specific modification of proteins, peptides, or biomolecules.
- Imaging: Synthesis of fluorescent or radiolabeled probes.
- Diagnostics: Functionalization for biosensors and assay development.
- Drug Delivery: Preparation of targeted drug conjugates.
- Chemical Biology: Studies in live-cell or complex biological environments.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
