Tetrazine-Biotin is a bifunctional reagent that combines a tetrazine group for rapid, bioorthogonal IEDDA reactions with strained alkenes (e.g., TCO) and a biotin moiety for high-affinity binding to avidin or streptavidin. This versatile compound is widely used in labeling, purification, and imaging applications in chemical biology and diagnostics.
Features
- Tetrazine Group: Enables fast and selective conjugation with TCO-containing molecules.
- Biotin Moiety: Provides strong, non-covalent binding to avidin/streptavidin systems.
- Bioorthogonal Reactivity: High specificity, even in complex biological environments.
- High Purity: ≥95% for consistent and reliable results.
- Biocompatibility: Suitable for in vitro and in vivo applications.
Applications
- Labeling: Site-specific tagging of biomolecules for detection or isolation.
- Purification: Biotin-streptavidin systems for targeted molecule enrichment.
- Imaging: Conjugation of fluorescent or radiolabeled probes for diagnostics.
- Chemical Biology: Studies in live-cell environments or complex systems.
- Therapeutics: Development of targeted drug delivery systems.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
