Mal-NH-Boc
Mal-NH-Boc is a high-purity heterobifunctional linker with a maleimide group for selective thiol coupling and a tert-butoxycarbonyl (Boc) protected amine for controlled deprotection. This design enables orthogonal conjugation, allowing sequential functionalization steps. The maleimide forms stable thioether bonds with sulfhydryl groups, while the protected amine can be revealed under mild acidic conditions for further coupling, making it especially ideal for multi-step bioconjugation and material modification.
Key Features and Benefits
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Maleimide Group: Reacts selectively with thiols for stable thioether bond formation.
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Boc-Protected Amine: Allows controlled deprotection for sequential conjugation.
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Orthogonal Reactivity: Supports multi-step synthesis without cross-reactivity.
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High Purity: Supplied at >95% purity for consistent performance.
Applications
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Site-specific protein or peptide modification.
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Antibody–drug conjugate (ADC) development.
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Multi-step orthogonal labeling strategies.
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Nanoparticle and surface functionalization.
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Biomaterial engineering.
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid moisture to maintain reactivity and Boc protection.
Mal-NH-Boc offers thiol-selective maleimide coupling and a Boc-protected amine for orthogonal functionalization specifically in advanced bioconjugation applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
