TCO-PEG4-CH2 NHS ester
TCO-PEG4-CH2 NHS ester is a high-purity heterobifunctional linker. It combines a trans-cyclooctene (TCO) group for rapid, catalyst-free IEDDA cycloaddition with tetrazines and an NHS ester for efficient amine coupling. The PEG4 spacer improves solubility and flexibility while reducing steric hindrance, making it ideal for fast, selective conjugations in both aqueous and organic systems.
Key Features and Benefits
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TCO Group: Enables ultrafast, catalyst-free click reactions with tetrazines.
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NHS Ester: Reacts efficiently with primary amines for stable amide bond formation.
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PEG4 Spacer: Improves solubility and reduces steric interference.
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High Purity: Suitable for sensitive bioconjugation applications.
Applications
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Site-specific protein and antibody labeling.
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Bioorthogonal pretargeting in imaging and drug delivery.
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Preparation of multifunctional bioconjugates.
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Click-to-release and triggered payload delivery systems.
Storage and Handling
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Storage: Store at –20 °C, protected from light and moisture.
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Handling: Use dry solvents; minimize air exposure; handle under inert atmosphere if possible.
This product is a dual-functional linker combining ultrafast TCO-tetrazine ligation with efficient amine-reactive NHS chemistry, especially ideal for constructing advanced bioconjugates and pretargeting systems.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
