TCO-PEG12-NHS ester
This product is a heterobifunctional PEG linker containing a trans-cyclooctene (TCO) group, a PEG12 spacer, and an NHS ester. It specifically enables rapid tetrazine click chemistry and efficient amine conjugation, providing solubility and long-chain flexibility.
Key Features and Benefits
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TCO Group: Reacts rapidly with tetrazines via IEDDA click chemistry.
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NHS Ester: Couples efficiently with primary amines to form stable amide bonds.
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PEG12 Spacer: Provides long-chain flexibility, solubility, and reduced steric hindrance.
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Dual Reactivity: Combines click chemistry with amine coupling.
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High Purity: Ensures reproducibility in sensitive bioconjugation workflows.
Applications
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Bioconjugation: Links tetrazine-modified molecules with amine-containing biomolecules.
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Probe Development: Builds multifunctional probes for diagnostics and imaging.
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Drug Delivery: Provides PEG scaffolds with click and amine-reactive handles.
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Material Science: Functionalizes nanoparticles, surfaces, and polymers with dual groups.
Storage and Handling
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged exposure to moisture.
This product integrates TCO click reactivity with amine-reactive NHS ester chemistry in a PEG12 scaffold, specifically offering solubility and flexible dual conjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
