t-Boc-Aminooxy-PEG7-amine
t-Boc-Aminooxy-PEG7-amine is a high-purity PEG linker with a t-Boc-protected aminooxy group and a primary amine. Its PEG7 spacer enhances solubility and flexibility, specifically enabling efficient conjugations in aqueous or organic media. The aminooxy group couples with aldehydes or ketones after deprotection, while the amine reacts with carboxylic acids or NHS esters for orthogonal bioconjugation and surface modification.
Key Features and Benefits
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Protected Aminooxy Group: t-Boc protection allows controlled deprotection for oxime ligation with aldehydes/ketones.
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Primary Amine: Reacts efficiently with carboxyl or NHS ester groups to form stable amide bonds.
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PEG7 Spacer: Enhances solubility, flexibility, and accessibility of reactive groups.
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Heterobifunctional Design: Enables orthogonal, site-specific conjugations in multi-step workflows.
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High Purity: Supplied at >95% purity for reproducible performance.
Applications
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Site-specific protein or peptide modification.
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Orthogonal labeling using oxime ligation and amide coupling.
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Surface and nanoparticle functionalization.
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Development of targeted drug delivery systems.
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Bioconjugation in diagnostics and imaging.
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid moisture to preserve reactivity and Boc protection.
This product offers orthogonal conjugation through a protected aminooxy group and a primary amine, linked by a PEG7 spacer specifically for solubility and flexibility in advanced bioconjugation applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
