t-Boc-Aminooxy-PEG4-azide linker contains an azide group and Boc-protected amino group. The PEG spacer increases the aqueous solubility of the resulting compound. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The Boc group can be deprotected under mild acidic conditions to form the free aminooxy group. The aminooxy has been used to conjugate with carbonyl bearing (ketone and aldehyde) biomolecules to form oxime for reversible linkage spacer.Oxime ligation is one of the hot topics in the field of bioconjugation of molecules due to its chemoselectivity and hydrolytic stability.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.