(S,R,S)-AHPC-PEG4-Azide
(S,R,S)-AHPC-PEG4-Azide is a high-purity heterobifunctional linker that combines an (S,R,S)-AHPC ligand for targeted protein degradation with an azide group specifically for copper-catalyzed azide–alkyne cycloaddition (CuAAC) or strain-promoted azide–alkyne cycloaddition (SPAAC) “click” chemistry. The PEG4 spacer enhances solubility, flexibility, and reduces steric hindrance, enabling efficient orthogonal bioconjugation in both aqueous and organic systems.
Key Features and Benefits
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(S,R,S)-AHPC Ligand – Binds to the von Hippel–Lindau (VHL) E3 ligase complex for PROTAC design
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Azide Group – Supports CuAAC and SPAAC click chemistry for modular assembly
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PEG4 Spacer – Improves solubility and accessibility of reactive groups
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Orthogonal Reactivity – Allows sequential and site-specific conjugations without cross-reactivity
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High Purity – >95% purity for consistent and reproducible performance
Applications
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PROTAC (Proteolysis Targeting Chimera) synthesis
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Dual-functional bioconjugation strategies
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Targeted protein degradation research
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Development of multifunctional chemical probes
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Drug discovery and therapeutic design
Storage and Handling
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Store at –20 °C, dry, and protected from light
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Use anhydrous solvents such as DMSO or DMF for dissolution
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Avoid prolonged exposure to moisture to prevent degradation
This product combines a VHL-binding AHPC ligand with an azide group for click chemistry, connected by a PEG4 spacer for solubility and flexibility, making it especially ideal for PROTAC synthesis and advanced bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.