SPDP-PEG8-tBu ester
This product is a cleavable heterobifunctional linker containing an SPDP (succinimidyl 3-(2-pyridyldithio)propionate) disulfide unit, an eight-unit PEG spacer, and a protected t-butyl ester. The SPDP group provides a cleavable disulfide bond for reductive release, while the t-butyl ester protects the carboxyl group until deprotection is desired. The PEG8 chain enhances solubility and flexibility, making this reagent especially useful for controlled bioconjugation and stepwise linker strategies.
Key Features and Benefits
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SPDP Moiety: Introduces a cleavable disulfide linkage for controlled release.
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t-Butyl Ester: Protects the acid functionality for stepwise modification.
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PEG8 Spacer: Improves solubility and reduces steric hindrance.
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Cleavable Design: Allows reversible conjugation in drug delivery and probe systems.
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High Purity: Produced to ≥95% purity for reliable performance.
Applications
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Bioconjugation: Links biomolecules through thiol and carboxyl chemistry.
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Drug Delivery: Enables controlled release of payloads via disulfide cleavage.
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Probe Development: Builds multifunctional cleavable probes for imaging and diagnostics.
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Synthetic Chemistry: Serves as an intermediate for protected stepwise linkers.
Storage and Handling
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Storage: Store at –20 °C in a sealed, moisture- and light-protected container.
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Handling: Deprotect t-butyl ester under mild acidic conditions; use freshly prepared solutions.
This product combines cleavable disulfide chemistry with a protected acid handle on a PEG8 chain, specifically offering flexibility for controlled bioconjugation workflows.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
