SPDP-PEG36-acid
This product is a cleavable linker with an SPDP disulfide, a PEG36 spacer, and a terminal carboxyl. It offers redox-sensitive release, excellent solubility, and amide-coupling capability, making it especially valuable for bioconjugation, ADCs, and drug delivery.
Key Features and Benefits
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SPDP Moiety: Introduces a disulfide bond for redox-sensitive release.
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PEG36 Spacer: Long, hydrophilic chain improves solubility and reduces steric hindrance.
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Carboxylic Acid Group: Couples efficiently with amines for stable amide bonds.
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Extended Reach: Provides long spacing for improved biomolecule accessibility.
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High Purity: Produced to ≥95% purity for reproducibility in research workflows.
Applications
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Antibody–Drug Conjugates (ADCs): Functions as a cleavable linker for controlled drug release.
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Bioconjugation: Couples disulfide-cleavable linkers to proteins, peptides, or probes.
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Drug Delivery: Builds PEGylated therapeutics with redox-sensitive release.
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Probe Development: Creates cleavable probes for imaging and diagnostics.
Storage and Handling
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Storage: Store at –20 °C in a sealed, desiccated container.
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Handling: Dissolve freshly before use in dry solvent; avoid repeated freeze–thaw cycles.
This product integrates disulfide cleavability with an extended PEG spacer and carboxyl reactivity, specifically providing a powerful tool for ADC design, bioconjugation, and targeted drug delivery.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
