(S)-2,6-Bis-(m-PEG8)-amidohexanoic Acid (CAS: 2353409-77-3) functions as a PEG-based linker frequently used in drug development and biochemical research. Its structure includes two methoxy-PEG8 (m-PEG8) chains attached to a chiral hexanoic acid backbone, enhancing water solubility and overall reducing steric hindrance. This design supports efficient bioconjugation and targeted drug delivery, making it significantly valuable for synthesizing proteolysis-targeting chimeras (PROTACs) and other therapeutic molecules.
Key Features:
- Dual m-PEG8 Chains:
- Improve water solubility, ensuring compatibility with aqueous environments.
- Minimize steric hindrance, enabling better conjugation efficiency.
- Chiral Hexanoic Acid Backbone:
- Provides structural stability and chiral specificity, important for drug development.
Applications:
- PROTAC Synthesis:
- Acts as a linker in designing PROTAC molecules that degrade target proteins via the ubiquitin-proteasome system.
- Bioconjugation:
- Connects biomolecules such as proteins, peptides, and small molecules through stable covalent bonds.
Handling and Storage:
- Molecular Formula: C₄₂H₈₂N₂O₂₂
- Molecular Weight: 967.10 g/mol
- Storage Recommendations:
- Keep in a cool, dry place, protected from light and moisture, to maintain stability.
Overall, this product supports a wide range of applications, from bioconjugation to targeted drug development. Furthermore, its hydrophilic PEG chains and chiral structure make it essential for advanced chemical synthesis, accordingly enabling precise molecular assembly and efficient therapeutic design.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
