Propargyl-PEG3-Azide
This high-purity heterobifunctional PEG linker has a terminal alkyne for CuAAC and an azide for CuAAC or SPAAC. The PEG3 spacer enhances solubility, flexibility, and reduces steric hindrance for especially efficient, orthogonal bioconjugation in aqueous and organic systems.
Key Features and Benefits
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Alkyne Group – Enables chemoselective CuAAC click reactions with azides.
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Azide Group – Compatible with CuAAC and SPAAC for bioorthogonal labeling.
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PEG3 Spacer – Enhances solubility, reduces steric hindrance, and improves accessibility of reactive groups.
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Orthogonal Reactivity – Allows sequential and site-specific modifications without cross-reactivity.
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High Purity – Supplied at >95% purity for reliable, reproducible results.
Applications
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Dual-click linker for orthogonal conjugation strategies
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Protein, peptide, and antibody modification
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Multifunctional probe and imaging agent synthesis
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Drug delivery and ADC linker chemistry
Storage and Handling
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Storage: –20 °C, dry, protected from light
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Handling: Use anhydrous solvents (DMSO, DMF); avoid prolonged moisture exposure to preserve reactivity
This product combines an alkyne and an azide for versatile click chemistry, connected by a PEG3 spacer for solubility and flexibility, especially ideal for orthogonal bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
