Pomalidomide-PEG4-Azide
This product is a heterobifunctional linker combining pomalidomide, a cereblon (CRBN)-binding ligand, with a PEG4 spacer and a terminal azide group. This design provides solubility, steric flexibility, and click-ready functionality, making it especially effective for PROTAC development, drug delivery, and probe design.
Key Features and Benefits:
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Pomalidomide Moiety: Recruits CRBN in PROTAC and targeted degradation strategies.
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Azide Group: Enables CuAAC or SPAAC click chemistry with alkynes.
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PEG4 Spacer: Enhances solubility and reduces steric hindrance.
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Dual Functionality: Combines CRBN binding with bioorthogonal reactivity.
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High Purity: Ensures reproducibility in drug discovery workflows.
Applications:
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PROTAC Development: Builds CRBN-targeting linkers for protein degradation.
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Drug Delivery: Supports PEGylated scaffolds with enhanced solubility.
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Probe Development: Creates functional probes for mechanistic and imaging studies.
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Bioconjugation: Integrates azide chemistry with ligand-directed design.
Storage and Handling:
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO); avoid prolonged light exposure.
This product combines cereblon-binding pomalidomide with click-ready azide functionality, specifically offering versatility for PROTAC design and multifunctional conjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
