Proteins conjugated to Picolyl Azide-Gly-Gly-Gly can be further modified with alkyne- or DBCO-containing molecules creating site-specific protein conjugates. Examples of creating protein conjugates using sortagging include site-specifically PEGylating proteins, site-specific protein-lipid conjugates, and constructing peptides and glycosylphosphatidylinositol chimeras. Sortase has also been used in peptide synthesis to cyclize peptides to create macrocyclic peptides, glycopeptides and protein−protein conjugates.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
