PFI-3 CAS:1819363-80-8 is significantly selective for PB1(5) and SMARCA2/4 over 36 other tested kinases. PFI-3 is a potent inhibitor of cell-active protein interactions, it is a bromodomain Selective chemical probes. PFI-3 is a probe that binds tightly to the structurally similar SMARCA4 bromodomain and PB1 (bromodomain 5) with Kd values of 89 and 48 nM, respectively. PFI-3 was screened in a commercial screening panel consisting of 102 cellular receptors and 30 enzymatic assays, showing only interactions with four GPCRs with micromolar affinity and no significant additional outside the BRD family interaction, confirming its excellent broader pharmacological selectivity.
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![l-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)-lHpyrazolo [3,4-d]pyrimidin-l-yl]-l-piperidinyl]-2-propyn-l-one](https://e1752fbe.rocketcdn.me/wp-content/uploads/AP14272-CAS-936563-91-6-1-e1686054563587.png)
