p-SCN-Bn-DOTA
p-SCN-Bn-DOTA is a high-purity bifunctional macrocyclic chelator featuring a para-isothiocyanatobenzyl group for stable conjugation to biomolecules and a DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) core for strong metal ion complexation. The isothiocyanate group reacts readily with primary amines under mild conditions to form stable thiourea linkages, while the DOTA moiety enables chelation of a wide range of radiometals and lanthanides for imaging, diagnostics, and therapeutic applications.
Key Features and Benefits
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Isothiocyanate Functional Group: Reacts with amines to form stable thiourea bonds.
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DOTA Chelator: Strongly binds metals such as Ga³⁺, Cu²⁺, Y³⁺, Lu³⁺, and Gd³⁺.
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Bifunctional Design: Enables simultaneous biomolecule conjugation and radiometal chelation.
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High Thermodynamic Stability: Ensures in vivo stability of metal complexes.
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High Purity: Supplied at >95% purity for reproducible labeling performance.
Applications
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Radiolabeling peptides, antibodies, and proteins.
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MRI contrast agent development (e.g., Gd³⁺-DOTA conjugates).
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PET/SPECT imaging using ^68Ga, ^64Cu, ^177Lu, or ^90Y.
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Targeted radiotherapy and theranostics.
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Metal-based biochemical probes.
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Handling: Use anhydrous solvents or aqueous buffers at neutral pH; avoid prolonged exposure to strong acids or bases.
p-SCN-Bn-DOTA combines an isothiocyanate group for amine conjugation with a DOTA chelator for strong, stable radiometal complexation, making it ideal for targeted imaging and therapy applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
