N,N-Bis(PEG2-azide)-N-PEG2-propionic NHS Ester
This product is a multifunctional PEG-based linker featuring two terminal azides and an N-hydroxysuccinimide (NHS) ester, connected through short PEG2 spacers. The dual azides enable bioorthogonal click chemistry, while the NHS ester allows efficient coupling with primary amines, making this reagent ideal for multivalent bioconjugation and advanced material applications.
Key Features and Benefits:
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Dual Azides: Support CuAAC and SPAAC click chemistry with alkyne partners.
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NHS Ester: Couples rapidly with amines to form stable amide bonds.
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PEG2 Spacers: Provide compact hydrophilicity and flexibility.
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High Purity: Ensures reproducibility in sensitive conjugation workflows.
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Multifunctionality: Combines bioorthogonal and amine-reactive handles in one reagent.
Applications:
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Bioconjugation: Enables dual azide labeling plus amine coupling in a single molecule.
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Click Chemistry: Supports efficient and selective protein, peptide, or polymer modification.
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Drug Delivery: Facilitates PEGylated linker–payload systems with enhanced solubility.
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Surface Functionalization: Functionalizes nanoparticles, hydrogels, and biomaterials.
Storage and Handling:
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Storage: Store at –20 °C in a dry, light-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO) to maintain NHS and azide reactivity.
This product offers multifunctionality with dual click handles and an amine-reactive group, making it an especially powerful tool for orthogonal conjugation and advanced bioconjugation strategies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
