N-Mal-N-bis(PEG4-acid) (CAS: 2100306-52-1) is a maleimide-terminated PEG derivative with two carboxylic acid groups. The maleimide group reacts specifically with thiol (-SH) groups, forming stable thioether linkages. The carboxylic acids allow conjugation with amine-containing molecules, facilitating a wide range of bioconjugation applications.
Key Features:
- Maleimide Group: Enables specific conjugation with thiol groups, forming stable thioether linkages.
- PEG Spacer: The four-unit PEG chain enhances solubility and flexibility, reducing steric hindrance.
- Carboxylic Acid Termini: Allow conjugation with amine-containing molecules for diverse applications.
Applications:
- Antibody-Drug Conjugates (ADCs): Links cytotoxic agents to antibodies for targeted drug delivery.
- Protein Labeling: Tags proteins for detection in fluorescence assays.
- Biomolecule Conjugation: Facilitates attachment of various molecules to biomolecules for research and therapeutic purposes.
Handling and Storage:
- Storage: Store at -20°C, protected from light and moisture.
- Handling: Use standard laboratory precautions when handling this reagent.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
