Mal-PEG4-Propargyl
Mal-PEG4-Propargyl is a high-purity heterobifunctional PEG linker with a maleimide group for thiol-specific conjugation and a terminal propargyl group for copper-catalyzed azide–alkyne cycloaddition (CuAAC) click chemistry. The PEG4 spacer enhances solubility, flexibility, and reduces steric hindrance, enabling efficient bioconjugation in both aqueous and organic systems. This design is especially ideal for orthogonal conjugation strategies requiring sequential thiol coupling and click chemistry.
Key Features and Benefits
-
Maleimide Group: Reacts selectively with thiols to form stable thioether bonds.
-
Propargyl Group: Compatible with CuAAC click chemistry for azide conjugation.
-
PEG4 Spacer: Improves solubility, flexibility, and accessibility of reactive groups.
-
Heterobifunctional Design: Enables orthogonal and sequential modification strategies.
-
High Purity: Supplied at >95% purity for consistent and reproducible results.
Applications
-
Stepwise Bioconjugation: Combine thiol labeling with click chemistry in a single molecule.
-
Protein and Peptide Modification: Introduce clickable alkynes to thiol-containing biomolecules.
-
Nanoparticle and Surface Functionalization: Equip surfaces with thiol- and azide-reactive handles.
-
Drug Delivery Systems: Create multifunctional linkers for targeted therapeutic delivery.
-
Diagnostic and Imaging Probes: Prepare dual-labeled probes with orthogonal chemistries.
Storage and Handling
-
Storage: Store at –20 °C, dry, and protected from light.
-
Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged exposure to moisture to maintain reactivity.
Mal-PEG4-Propargyl combines thiol reactivity and click chemistry capability in a hydrophilic PEG4 framework, offering versatility specifically for orthogonal bioconjugation in therapeutics, diagnostics, and materials science.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
