Mal-NH-PEG2-BCN is a heterobifunctional cross-linker designed for bioconjugation. It contains a maleimide group for conjugating with thiol-containing molecules and a BCN (bicyclononyne) group for click chemistry with azide-containing molecules. The two-unit PEG spacer improves solubility and flexibility, reducing steric hindrance.
Key Features:
- Maleimide Group: Allows specific conjugation with thiol groups, forming stable thioether linkages.
- BCN Group: Enables efficient click chemistry with azide-containing molecules, forming stable triazoles.
- PEG Spacer: Enhances solubility and flexibility, reducing steric hindrance.
Mal-NH-PEG2-BCN Applications:
- Antibody-Drug Conjugates (ADCs): Links cytotoxic drugs to antibodies for targeted drug delivery.
- Protein Labeling: Tags proteins for fluorescence assays and detection.
- Biomolecule Conjugation: Attaches molecules to biomolecules for research and therapeutic uses.
Handling and Storage:
- Storage: Store at -20°C, away from light and moisture.
- Handling: Follow standard laboratory precautions when using this reagent.
Ref:
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
