Mal-NH-PEG-SPA, MW 4K (Maleimide-NH-PEG-Succinimidyl Propionate) is a versatile compound used in pharmaceutical research and development as a cross-linking agent for various biomolecules. This compound consists of three distinct functional groups: a maleimide, a succinimidyl propionate, and a polyethylene glycol (PEG) linker.
The maleimide group is a reactive thiol-specific moiety that can covalently attach to sulfhydryl (-SH) groups on cysteine residues in proteins, peptides, and other biomolecules. The succinimidyl propionate group is a reactive ester that can react with primary amines (-NH2) to form stable amide bonds. The PEG linker provides hydrophilicity and flexibility to the molecule, allowing for improved solubility and reduced immunogenicity.
In pharmaceutical research and development, Mal-NH-PEG-SPA, MW 4K is commonly used in the production of drug delivery systems, such as liposomes, nanoparticles, and conjugates. By conjugating Mal-NH-PEG-SPA, MW 4K to biomolecules, it is possible to control drug release, increase drug stability, and target specific cells or tissues. Furthermore, the PEG linker can improve the pharmacokinetic properties of the drug delivery system, such as reducing renal clearance and increasing circulation time.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.