Product Description: FKBP12 PROTAC dTAG-13 (CAS: 2064175-41-1)
FKBP12 PROTAC dTAG-13 is an efficient PROTAC (Proteolysis-Targeting Chimera) designed to selectively degrade FKBP12F36V fusion proteins and mutant FKBP12. It contains a dTAG-13 group that engages FKBP12F36V and CRBN, triggering rapid, targeted degradation via the proteasome. This powerful tool effectively controls protein levels and allows researchers to study specific proteins in biological research.
Key Features:
- dTAG-13 Group: Efficiently targets and degrades FKBP12F36V fusion proteins.
- PROTAC Technology: Leverages the cell’s natural degradation system to quickly remove proteins.
- CRBN Engagement: Specifically recruits FKBP12F36V for proteasomal degradation.
Applications:
- Protein Degradation: Precisely removes FKBP12F36V-fused proteins, aiding protein function studies.
- Drug Discovery: Supports the development of therapies focused on targeted protein degradation.
- Biological Research: Provides a precise tool for degrading proteins fused to FKBP12F36V, enabling functional analysis.
Advantages:
- Precise Targeting: Selectively targets FKBP12F36V, minimizing off-target effects.
- Efficient Degradation: Promotes rapid protein removal through the proteasome pathway.
- Versatile Use: Works well in protein function research and therapeutic development.
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