DLin-KC2-DMA CAS:1190197-97-7 is an ionizable cationic lipid for siRNA delivery. It was formulated and characterized in SNALP and demonstrated in vivo activity at siRNA doses as low as 0.01 mg/kg in rodents and 0.1 mg/kg in non-human primates. Compared to the previous generation lipid DLin-DMA, DLin-KC2-DMA is 100-fold and 1000-fold more potent in silencing liver genes (factor VII), respectively.
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