Diketone-PEG12-DBCO
This product is a heterobifunctional linker that integrates a reactive diketone group, a twelve-unit PEG chain, and a dibenzocyclooctyne (DBCO) moiety. The diketone serves as a versatile handle for oxime or hydrazone ligation with aminooxy or hydrazide groups, while the DBCO enables rapid, copper-free SPAAC click chemistry with azides. The PEG12 spacer provides excellent solubility, flexibility, and extended reach, making this reagent especially valuable for dual-functional bioconjugation and therapeutic design.
Key Features and Benefits
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Diketone Group: Reacts with aminooxy or hydrazide partners via oxime/hydrazone ligation.
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DBCO Moiety: Supports ultrafast, copper-free SPAAC click chemistry with azides.
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PEG12 Spacer: Enhances solubility, flexibility, and reduces steric hindrance.
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Dual Reactivity: Combines bioorthogonal click chemistry with reversible ligation.
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High Purity: Produced to ≥95% purity for reliable performance.
Applications
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Bioconjugation: Links azide- and hydrazide/aminooxy-modified biomolecules.
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Protein and Antibody Labeling: Provides orthogonal handles for multifunctional modifications.
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Probe Development: Builds advanced probes with dual reactivity for imaging.
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Drug Delivery: Functions as a dual-functional linker in therapeutic systems.
Storage and Handling
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Storage: Store at –20 °C in a sealed, moisture- and light-protected container.
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Handling: Use freshly prepared solutions; avoid repeated freeze–thaw cycles.
This product combines diketone ligation chemistry with copper-free click reactivity on a PEG12 scaffold, specifically offering a versatile tool for multifunctional conjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.