DBCO-PEG5-DBCO
This product is a homobifunctional linker containing two dibenzocyclooctyne (DBCO) groups connected by a PEG5 spacer. The DBCO groups enable rapid, copper-free strain-promoted azide–alkyne cycloaddition (SPAAC) with azides, while the PEG5 chain improves solubility and provides flexibility. This design makes it an especially efficient crosslinker for bioconjugation and probe development.
Key Features and Benefits
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Dual DBCO Groups: React efficiently with azides via copper-free click chemistry.
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PEG5 Spacer: Enhances solubility and reduces steric hindrance.
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Homobifunctional Design: Crosslinks azide-functionalized biomolecules or polymers.
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Bioorthogonal Reactivity: Suitable for selective labeling under physiological conditions.
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High Purity: Manufactured to ≥95% purity for reliable results.
Applications
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Bioconjugation: Links two azide-modified biomolecules or probes.
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Crosslinking: Bridges polymers, proteins, or nanoparticles through SPAAC chemistry.
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Probe Development: Builds multifunctional click-compatible probes for imaging and diagnostics.
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Drug Delivery: Supports design of dual-reactive or crosslinked carriers.
Storage and Handling
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Prepare fresh solutions before use; avoid repeated freeze–thaw cycles.
This product offers dual click handles on a PEG5 backbone, making it an especially versatile crosslinker for copper-free bioconjugation and advanced material applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
