DBCO-NH-PEG7-NHS Ester
This high-purity heterobifunctional PEG linker features a dibenzocyclooctyne (DBCO) for rapid, copper-free SPAAC click chemistry with azides and an NHS ester for efficient amine coupling. The PEG7 spacer specifically improves solubility, flexibility, and reduces steric hindrance for effective orthogonal bioconjugation in aqueous and organic systems.
Key Features and Benefits
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DBCO Group – Enables ultra-fast, copper-free SPAAC click chemistry with azides.
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NHS Ester – Reacts selectively with primary amines for stable amide bond formation.
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PEG7 Spacer – Improves solubility, flexibility, and accessibility while reducing steric hindrance.
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Orthogonal Reactivity – Supports sequential, site-specific modifications without cross-reactivity.
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High Purity – Supplied at >95% purity for consistent results.
Applications
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Dual-functional linker for orthogonal conjugation
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Protein, peptide, and antibody modification
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Antibody–drug conjugate (ADC) linker chemistry
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Nanoparticle and surface functionalization
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Imaging and diagnostic probe synthesis
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Handling: Use anhydrous solvents such as DMSO or DMF; avoid prolonged moisture exposure.
This product links copper-free click chemistry and amine coupling via a PEG7 spacer for especially versatile bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
