DBCO-NH-PEG6-Mal
This product is a heterobifunctional linker featuring a dibenzocyclooctyne (DBCO) group for copper-free SPAAC click chemistry and a maleimide group for selective thiol conjugation. The PEG6 spacer provides hydrophilicity and flexibility, making it especially effective for dual-functional bioconjugation, probe development, and ADC design.
Key Features and Benefits:
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DBCO Group: Enables rapid, catalyst-free SPAAC click chemistry with azides.
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Maleimide Group: Selectively reacts with thiols to form stable thioether bonds.
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PEG6 Spacer: Enhances solubility, flexibility, and steric accessibility.
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Dual Reactivity: Supports orthogonal, multifunctional conjugation strategies.
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High Purity: Ensures reproducibility in advanced research and therapeutic workflows.
Applications:
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Bioconjugation: Links biomolecules via thiol and azide/alkyne handles.
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ADC Development: Provides dual-reactive linker systems for antibody–drug conjugates.
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Probe Development: Builds multifunctional probes for imaging and diagnostics.
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Drug Delivery: Improves solubility and circulation properties of therapeutic conjugates.
Storage and Handling:
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO); avoid premature hydrolysis of maleimide.
This product integrates copper-free click chemistry with thiol conjugation in a PEG6 scaffold, specifically providing solubility, versatility, and dual reactivity for advanced bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
