DBCO-NH-PEG5-acid
This product is a heterobifunctional PEG linker containing a dibenzocyclooctyne (DBCO) group, a PEG5 spacer, and a terminal carboxylic acid. It specifically enables copper-free click chemistry and amide coupling, offering solubility, flexibility, and dual reactivity.
Key Features and Benefits
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DBCO Group: Reacts rapidly with azides via SPAAC copper-free click chemistry.
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Carboxylic Acid: Couples efficiently with primary amines to form amide bonds.
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PEG5 Spacer: Provides solubility, moderate flexibility, and reduced steric hindrance.
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Dual Reactivity: Combines bioorthogonal click chemistry with amide coupling.
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High Purity: Ensures reproducibility in sensitive conjugation workflows.
Applications
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Bioconjugation: Links azide-modified biomolecules with amine partners.
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Probe Development: Builds multifunctional probes for diagnostics and imaging.
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Drug Delivery: Provides PEG scaffolds with orthogonal reactive groups.
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Material Science: Functionalizes nanoparticles, polymers, and surfaces with dual handles.
Storage and Handling
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged exposure to moisture.
This product integrates copper-free click chemistry with carboxyl reactivity in a PEG5 scaffold, specifically offering solubility, flexibility, and multifunctional conjugation capability.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
