DBCO-NH-PEG2-Biotin
This product is a multifunctional PEG linker containing a dibenzocyclooctyne (DBCO) group, a PEG2 spacer, and a biotin moiety. It specifically enables copper-free click chemistry with azides and high-affinity streptavidin binding in a compact, soluble scaffold.
Key Features and Benefits
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DBCO Group: Reacts rapidly with azides via strain-promoted azide–alkyne cycloaddition (SPAAC).
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Biotin Moiety: Provides strong affinity binding to streptavidin and avidin systems.
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PEG2 Spacer: Improves solubility while maintaining compact molecular spacing.
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Dual Reactivity: Combines bioorthogonal click chemistry with biotin affinity capture.
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High Purity: Ensures reproducibility in sensitive bioconjugation workflows.
Applications
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Bioconjugation: Links azide-modified biomolecules with biotin-binding systems.
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Probe Development: Builds multifunctional probes for imaging and diagnostics.
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Drug Delivery: Provides PEG scaffolds with click and affinity handles.
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Material Science: Functionalizes nanoparticles, polymers, and surfaces with dual reactivity.
Storage and Handling
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged exposure to moisture.
This product integrates copper-free click reactivity with biotin–streptavidin binding in a PEG2 scaffold, specifically offering versatility for conjugation and probe design.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
