DBCO-NH-PEG12-amine
This product is a heterobifunctional linker featuring a dibenzocyclooctyne (DBCO) group, a long PEG12 spacer, and a terminal primary amine. The DBCO enables rapid, copper-free strain-promoted azide–alkyne cycloaddition (SPAAC) with azides, while the amine couples efficiently with carboxyls or activated esters. The PEG12 spacer specifically provides excellent solubility, flexibility, and extended reach, making this reagent highly useful for bioconjugation, drug delivery, and probe development.
Key Features and Benefits
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DBCO Group: Reacts rapidly with azides via copper-free SPAAC chemistry.
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Primary Amine: Couples readily with carboxyl or NHS esters to form amide bonds.
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PEG12 Spacer: Enhances solubility, flexibility, and biomolecule accessibility.
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Dual Reactivity: Supports orthogonal click chemistry and amide coupling.
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High Purity: Manufactured to ≥95% purity for reproducible results.
Applications
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Bioconjugation: Links azide- and carboxyl-functionalized biomolecules.
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Protein and Antibody Labeling: Provides long, flexible spacing for site-specific modifications.
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Probe Development: Builds dual-functional probes for imaging and diagnostics.
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Drug Delivery: Serves as a PEGylated linker for targeted therapeutic systems.
Storage and Handling
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Prepare fresh solutions before use; avoid repeated freeze–thaw cycles.
This product integrates bioorthogonal DBCO click reactivity with amine functionality on a long PEG chain, making it especially ideal for flexible and efficient conjugation strategies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
