DBCO-NH-PEG12-acid contains a carboxylic acid functional group (-COOH) and a Dibenzylcyclooctyne (DBCO) group attached to the PEG chain. The DBCO group is known for its ability to react with azide groups through copper-free click chemistry.
DBCO-NH-PEG12-acid has been extensively utilized in the development of novel drug conjugates, such as antibody-drug conjugates (ADCs). Its unique chemical properties allow for the site-specific conjugation of therapeutic agents, such as cytotoxic drugs, to antibodies or other targeting molecules that have been modified with azide groups. The resulting conjugates exhibit improved therapeutic efficacy and reduced toxicity, as the drug is delivered specifically to the target site and released only upon binding to the target molecule.
DBCO-NH-PEG12-acid has also been employed as a surface modifier in various biomedical applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
