DBCO-C4-PEG3-amine
This product is a heterobifunctional linker with a dibenzocyclooctyne (DBCO) group, a C4-PEG3 spacer, and a terminal amine. The DBCO specifically performs ultrafast, copper-free SPAAC click chemistry with azides and the amine couples efficiently with carboxyls or activated esters to form amide bonds. The C4-PEG3 spacer specifically improves solubility, reduces steric hindrance, and balances compactness with flexibility for bioconjugation.
Key Features and Benefits
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DBCO Group: Enables rapid, copper-free click chemistry with azides.
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Amine Group: Couples efficiently with carboxyls or NHS esters.
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C4-PEG3 Spacer: Provides solubility, flexibility, and moderate spacing.
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Dual Reactivity: Supports orthogonal bioorthogonal and amide coupling strategies.
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High Purity: Manufactured to ≥95% purity for reproducibility.
Applications
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Bioconjugation: Links azide- and carboxyl-containing biomolecules.
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Protein and Antibody Labeling: Adds dual handles for site-specific modification.
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Probe Development: Builds multifunctional probes for imaging and diagnostics.
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Drug Delivery: Serves as a modular linker in therapeutic conjugates.
Storage and Handling
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Storage: Store at –20 °C in a sealed, desiccated container.
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Handling: Prepare fresh solutions; avoid repeated freeze–thaw cycles.
This product combines copper-free click chemistry and amine coupling in a compact, flexible PEG scaffold, specifically providing a versatile tool for conjugation workflows.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
