Bis-PEG2-acid (CAS 19364-66-0) is a PEG linker containing two terminal carboxylic acid groups. Consequently, it is frequently used in chemical and biochemical applications. The hydrophilic PEG spacer significantly enhances solubility in aqueous environments, making it easier to handle in diverse research settings. As a result, this increased solubility makes it ideal for applications in bioconjugation and drug development, ensuring better compatibility in biological systems.
Key Features:
- Terminal Carboxylic Acids: These groups can react with primary or secondary amines in the presence of activators like EDC, DCC, or HATU, forming stable amide bonds. This capability allows for the conjugation of different biomolecules in a controlled sequence.
- Hydrophilic PEG Spacer: Improves the solubility of conjugates, making them suitable for aqueous environments and enhancing their biological compatibility.
Applications:
- Bioconjugation: Facilitates the linking of two biomolecules with amine groups for targeted drug delivery or diagnostic purposes.
- Drug Delivery: Commonly used in creating drug carriers that require increased solubility and stability in biological systems.
- Surface Modification: Useful in modifying surfaces for biosensors or other analytical tools that require precise chemical control.
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