Bis-Bromoacetamido-PEG11 (CAS: 951308-86-4) is a PEG derivative with two bromoacetamide groups. The PEG11 spacer boosts solubility and flexibility. The bromoacetamide groups react with nucleophiles, especially thiols, for bioconjugation. It is used in making PROTACs and bioconjugates by attaching biomolecules through nucleophilic substitution.
Key Features:
- Dual Reactivity: Two bromoacetamide groups react with thiols to form stable thioether bonds.
- PEG11 Spacer: Adds hydrophilicity and flexibility, reducing steric hindrance.
- Broad Use: Suitable for PROTACs, ADCs, and other precise bioconjugation.
Applications:
- PROTAC Synthesis: Links E3 ligase ligands to target proteins for protein degradation.
- Bioconjugation: Connects biomolecules like peptides and proteins using thiol-reactive chemistry.
- Drug Development: Helps create conjugates for targeted drug delivery and therapies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
