BCN-PEG4-acid (CAS: 2226472-38-2) is a bifunctional linker featuring a bicyclo[6.1.0]non-4-yne (BCN) group and a terminal carboxylic acid connected by a PEG4 spacer. The BCN group supports copper-free click chemistry with azide-functionalized molecules, while the carboxylic acid allows amide bond formation with primary amines. The PEG4 spacer enhances solubility and reduces steric hindrance, making this compound ideal for various bioconjugation applications.
Key Features:
- BCN Moiety: Enables copper-free click chemistry with azides.
- Carboxylic Acid: Forms stable amide bonds with primary amines using activators like EDC or HATU.
- PEG4 Spacer: Increases water solubility and minimizes steric interference.
BCN-PEG4-acid Applications:
- Bioconjugation: Attaches biomolecules via click chemistry or amide bond formation.
- Surface Modification: Enhances biocompatibility of nanoparticles, biomaterials, or drug delivery systems.
- Drug Delivery: Facilitates targeted therapeutic agent conjugation.
Handling and Storage:
- Molecular Formula: C₂₂H₃₅NO₈
- Molecular Weight: 441.52 g/mol
- Purity: ≥95%
- Storage: Store at -20°C, away from light and moisture.
This linker is commonly used in biomedical research, drug delivery, and materials science due to its versatility and efficient bioconjugation capabilities.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
