BCN-PEG3-Val-Cit
This product is a cleavable PEG linker containing a bicyclo[6.1.0]nonyne (BCN) group, a PEG3 spacer, and a Val-Cit dipeptide. It specifically enables copper-free click chemistry with azides and enzyme-cleavable functionality for controlled drug release.
Key Features and Benefits
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BCN Group: Performs strain-promoted azide–alkyne cycloaddition (SPAAC) without copper.
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PEG3 Spacer: Provides solubility and minimizes steric hindrance.
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Val-Cit Motif: Enzyme-cleavable sequence widely used in ADC linkers.
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Dual Functionality: Combines bioorthogonal click chemistry with cleavable peptide design.
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High Purity: Ensures reproducible results in sensitive workflows.
Applications
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Antibody–Drug Conjugates (ADCs): Provides a cleavable linker for targeted therapeutic release.
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Bioconjugation: Links azide-modified molecules to biomolecules or scaffolds.
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Drug Delivery: Enables enzyme-triggered release of payloads.
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Probe Development: Builds responsive probes for imaging and diagnostics.
Storage and Handling
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged exposure to moisture.
This product integrates copper-free click chemistry with an enzyme-cleavable Val-Cit sequence, specifically providing a versatile scaffold for ADCs and responsive conjugates.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
