BCN-PEG1-Val-Cit-OH
This product is a cleavable linker featuring a bicyclononyne (BCN) group, a short PEG1 spacer, and the dipeptide Val-Cit motif. The BCN enables rapid copper-free click chemistry, while the Val-Cit sequence is especially used as a protease-cleavable linker in antibody–drug conjugates (ADCs).
Key Features and Benefits
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BCN Handle: Provides strain-promoted azide–alkyne cycloaddition (SPAAC) for copper-free click chemistry.
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PEG1 Spacer: Enhances solubility while maintaining compact molecular design.
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Val-Cit Cleavable Linker: Recognized by cathepsin B and other proteases, enabling controlled drug release.
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ADC Compatibility: Optimized for antibody–drug conjugates and targeted therapeutic strategies.
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High Purity: Produced to ≥95% purity for reliable and reproducible performance.
Applications
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Antibody–Drug Conjugates: Serves as a cleavable linker for controlled drug release in cancer therapy.
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Bioconjugation: Couples BCN-functionalized drugs or payloads to azide-modified biomolecules.
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Targeted Delivery: Supports site-specific drug delivery strategies through bioorthogonal click chemistry.
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Chemical Biology: Enables construction of cleavable probes for mechanistic and therapeutic studies.
Storage and Handling
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Storage: Store at –20 °C in a sealed container, protected from moisture and light.
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Handling: Use under inert conditions when possible; avoid prolonged exposure to heat.
This product combines a BCN click handle with a cleavable Val-Cit motif, specifically providing a compact and efficient linker for ADC development, bioconjugation, and targeted delivery applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
