Azido-PEG1-Val-Cit-PAB-PNP
This product is a high-purity cleavable linker combining an azide group for copper-free click chemistry, a PEG1 spacer for enhanced solubility, and a valine–citrulline–p-aminobenzyl (Val-Cit-PAB) dipeptide moiety for enzyme-triggered release. The para-nitrophenyl (PNP) carbonate serves as an activated ester for nucleophilic substitution with amines or hydroxyl groups.
Key Features and Benefits
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Azide Group: Enables SPAAC or CuAAC bioconjugation.
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PEG1 Spacer: Improves water solubility and flexibility.
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Val-Cit-PAB Cleavable Linker: Stable in circulation; cleaved by cathepsin B in lysosomes.
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PNP Carbonate: Efficient leaving group for amine or alcohol coupling.
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High Purity: Ensures reproducible results in sensitive applications.
Applications
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Antibody–drug conjugate (ADC) payload attachment.
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Prodrug synthesis with controlled release.
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Bioconjugation requiring cleavable linkers.
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Targeted drug delivery research.
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Handling: Use anhydrous solvents such as DMF or DMSO; minimize exposure to moisture.
A cleavable azide-containing PEG1 linker with a Val-Cit-PAB moiety and PNP carbonate for efficient conjugation and enzyme-triggered release.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
