Acid-propionylamino-Val-Cit-OH
This product is a cleavable linker featuring a Val–Cit dipeptide and a terminal carboxylic acid for amide coupling. The propionylamino modification enhances stability and synthetic versatility, making this reagent especially useful for ADC linker design, drug delivery, and targeted bioconjugation.
Key Features and Benefits:
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Val–Cit Dipeptide: Cleaved by cathepsin B for selective intracellular drug release.
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Carboxylic Acid Group: Enables efficient amide bond formation with amines.
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Propionylamino Modification: Improves stability and conjugation options.
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High Purity: Provides reproducibility in bioconjugation and ADC workflows.
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Compact Design: Supports precise and stable linker–payload assembly.
Applications:
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ADC Development: Core linker for controlled protease-sensitive drug release.
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Drug Delivery: Enhances solubility and targeting of therapeutic molecules.
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Bioconjugation: Couples biomolecules through acid–amine linkages.
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Probe Development: Useful in designing protease-cleavable imaging or diagnostic tools.
Storage and Handling:
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Storage: Store at –20 °C in a tightly sealed, light-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO) for coupling reactions.
This product combines protease-cleavable Val–Cit functionality with a carboxylic acid handle, making it an especially valuable reagent for ADCs and targeted conjugation strategies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
