Acid-PEG12-t-butyl ester, also known as tert-butyl ester-functionalized polyethylene glycol 12 (t-Bu-PEG12), is a hydrophilic, biocompatible, and versatile reagent widely used in pharmaceutical research and development. The compound features a carboxylic acid group at one end and a tert-butyl ester group at the other end, facilitating the introduction of functional groups and enabling various bioconjugation applications.
Acid-PEG12-t-butyl ester is extensively employed in the development of bioconjugates, where it serves as a PEGylation reagent. PEGylation involves attaching polyethylene glycol (PEG) chains to biomolecules, such as proteins, peptides, and nucleic acids, to improve their physicochemical and pharmacokinetic properties. PEGylated bioconjugates demonstrate increased circulating half-life, reduced immunogenicity, and enhanced solubility, making them more suitable for therapeutic applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
