Acetobromo-alpha-D-glucuronic acid methyl ester

Acetobromo-alpha-D-glucuronic acid methyl ester

This product is a carbohydrate-derived intermediate featuring a glucuronic acid backbone protected as a methyl ester and substituted with an acetyl and bromide group. The bromide serves as a reactive leaving group for glycosylation reactions, specifically enabling the formation of glycosidic bonds. Its compact, functionalized design makes it an especially valuable building block in carbohydrate chemistry, glycoconjugate synthesis, and medicinal research.

Key Features and Benefits

• Reactive Bromide: Provides efficient glycosyl donor functionality.

• Methyl Ester Protection: Stabilizes the carboxyl group during synthesis.

• Acetyl Substitution: Enhances reactivity and selectivity in glycosylation.

• Carbohydrate Scaffold: Derived from glucuronic acid, useful in glycochemistry.

• High Purity: Produced to ≥95% purity for reliable synthetic performance.

Applications

• Carbohydrate Chemistry: Serves as a glycosyl donor for constructing oligosaccharides.

• Glycoconjugate Synthesis: Builds glycosylated peptides, proteins, or small molecules.

• Medicinal Chemistry: Supports drug discovery involving glycosylated derivatives.

• Probe Development: Precursor for carbohydrate-based imaging and diagnostic agents.

Storage and Handling

• Storage: Store at 2–8 °C in a sealed, desiccated container.

• Handling: Use under dry, inert conditions; bromides are moisture-sensitive and reactive.

This product combines a reactive bromide donor with methyl-protected glucuronic acid, making it an especially versatile intermediate for advanced glycosylation strategies.

AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.