{4-[3-(trifluoromethyl)-3H-diazirin-3-yl]phenyl}methanol

{4-[3-(Trifluoromethyl)-3H-diazirin-3-yl]phenyl}methanol

This product is a high-purity photoreactive compound featuring a trifluoromethyl diazirine moiety and a benzylic alcohol. The diazirine group generates reactive carbene species upon UV irradiation, enabling covalent crosslinking with nearby molecules, while the hydroxymethyl group provides a handle for further functionalization. This reagent is especially used in photoaffinity labeling, crosslinking studies, and proteomic research to identify binding interactions in complex biological systems.

Key Features and Benefits

• Photoreactive Diazirine: Generates carbene intermediates for covalent crosslinking under UV light.

• Trifluoromethyl Group: Enhances photostability and reactivity of the diazirine.

• Benzylic Alcohol: Allows further derivatization for probe or linker synthesis.

• High Purity: Supplied at >95% purity for reliable experimental performance.

• Versatile Utility: Suitable for chemical biology, proteomics, and materials science.

Applications

• Photoaffinity labeling for target identification.

• Protein–ligand and protein–protein interaction mapping.

• Development of photoreactive probes.

• Surface modification using photochemical crosslinking.

• Materials research requiring light-activated bonding.

Storage and Handling

• Storage: Store at –20 °C, dry, and protected from light.

• Handling: Avoid prolonged light exposure; use UV-protective glassware during preparation.

{4-[3-(Trifluoromethyl)-3H-diazirin-3-yl]phenyl}methanol combines a UV-activated diazirine crosslinker with a functional alcohol group for downstream conjugation specifically in photoaffinity labeling and photochemical crosslinking applications.

AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.